Leptospermum scoparium (Manuka)|

Leptosparones A–F (16), six new dimeric acylphloroglucinol derivatives with unprecedented skeletons, were isolated from Leptospermum scoparium. Compounds 1–3 and 5–6 are phenylpropanoyl-phloroglucinol dimers, while 4 is a phenylpropanoylphloroglucinol-isovalerylphloroglucinol hybrid. Structurally, these compounds represent the first examples of dimeric phloroglucinols with unprecedented C(7′)−C(8) linkage between the phloroglucinol core and the acyl side chain. Their structures were elucidated by comprehensive analyses of spectroscopic data, single crystal X-ray diffraction and chemical calculations. In addition, all compounds showed inhibitory effects against α-glucosidase with IC50 values ranging from 39.5 to 186.8 μM.

Xia, K., et al. (2021). “Dimeric Acylphloroglucinol Derivatives with New Skeletons from Leptospermum scoparium.” Chemistry & Biodiversity.Volume 18, Issue 6

https://doi.org/10.1002/cbdv.202100252

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